Title:
Lyophilized liposomes
Document Type and Number:
Japanese Patent JP6359717
Kind Code:
B2
Abstract:
A lyophilized gel-phase liposomal composition is provided which comprises more than one therapeutic and/or diagnostic agent, substantially no internal cryoprotectant, gel-phase liposomes with gel-to-liquid crystalline transition temperatures (Tc) that are at least 25°C, wherein the liposomes are 20 mol% or less cholesterol liposomes that are stabilized with at least 1% of a phosphatidylglycerol (PG) and/or a phosphoinositol (PI), and cryoprotectant external to said liposomes. The lyophilized gel-phase liposomal composition and said composition reconstituted in a suitable pharmaceutical carrier are provided for use in therapy.
Inventors:
Cabral-Lily, Donna
Mayr, lawrence
Tadi, paul
David, Watkins
Jen, Lee
Mayr, lawrence
Tadi, paul
David, Watkins
Jen, Lee
Application Number:
JP2017074348A
Publication Date:
July 18, 2018
Filing Date:
April 04, 2017
Export Citation:
Assignee:
Serator Pharmaceuticals, Inc.
International Classes:
A61K9/127; A61K9/19; A61K31/4745; A61K31/704; A61K31/7052; A61K31/7068; A61K47/24; A61K47/28; A61P35/00; A61P43/00
Domestic Patent References:
| JP2005509000A | ||||
| JP62501631A | ||||
| JP2001519776A | ||||
| JP2007533670A | ||||
| JP2006523713A | ||||
| JP6133308B2 |
Attorney, Agent or Firm:
Tomoko Nakatani