Title:
フルベン及びフルバレン類似体、及び癌治療におけるその使用
Document Type and Number:
Japanese Patent JP2010526100
Kind Code:
A
Abstract:
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are fulvene and/or fulvalene analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, as well as numerous inflammatory, degenerative and vascular diseases, including various ocular diseases. Representative fulvene and/or fulvalene analogs include fulvene and fulvalene analogs of various dyes, hormones, sugars, peptides, oligonucleotides, amino acids, nucleotides, nucleosides, and polyols. The compounds are believed to function, at least, by inhibiting Nox or ROS. In some embodiments, the Nox is one that is selectively expressed in cancer cells over normal cells, or one that is expressed in higher amounts in cancer cells over normal cells. Thus, the compounds are novel therapeutic agents for a variety of cancers and other diseases.
More Like This:
Inventors:
Arbiter Jack El.
Application Number:
JP2010506687A
Publication Date:
July 29, 2010
Filing Date:
May 02, 2008
Export Citation:
Assignee:
Emory University
International Classes:
C07C13/28; A61K31/015; A61K31/05; A61K31/085; A61K31/136; A61K31/16; A61K31/222; A61K31/351; A61K31/352; A61K31/357; A61K31/365; A61K31/403; A61K31/404; A61K31/4164; A61K31/42; A61K31/426; A61K31/444; A61K31/5375; A61K31/573; A61P1/00; A61P9/10; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P19/10; A61P25/00; A61P27/02; A61P27/04; A61P27/06; A61P27/12; A61P27/14; A61P35/00; A61P39/06; A61P43/00; C07C13/40; C07C13/465; C07C13/58; C07C25/18; C07C35/32; C07C39/23; C07C43/215; C07C43/23; C07C69/608; C07C211/50; C07C215/64; C07C233/44; C07C237/26; C07C275/64; C07D209/86; C07D213/22; C07D233/58; C07D233/68; C07D307/58; C07D309/36; C07D311/58; C07D311/60; C07D311/62; C07D311/82; C07D407/04; C07D471/10; C07D473/34; C07J9/00
Domestic Patent References:
| JPS62228049A | 1987-10-06 | |||
| JP2000515161A | 2000-11-14 | |||
| JPH11246619A | 1999-09-14 |
Other References:
JPN6013022850; Ｃｈｅｍｉｃａｌ Ａｂｓｔｒａｃｔｓ
JPN6013022852; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ （１９６５）， ８（３）， ３９０-２
JPN6013022854; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ （１９７３）， １６（４）， ４２１-５
JPN6013022855; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ （１９５４）， ７６， ３３５４
JPN6013022852; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ （１９６５）， ８（３）， ３９０-２
JPN6013022854; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ （１９７３）， １６（４）， ４２１-５
JPN6013022855; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ （１９５４）， ７６， ３３５４
Attorney, Agent or Firm:
Nagoya International Patent Service Corporation