Title:
フルベストラント製剤とその使用方法
Document Type and Number:
Japanese Patent JP7220712
Kind Code:
B2
Abstract:
The present disclosure provides methods of treating breast cancer including administering aqueous suspensions com-prising solubilized fulvestrant, non-solubilized fulvestrant particles having one or more of an LD Dv(1 0) between about 1.5 and about 2.1 microns, an LD Dv(50) between about 5.5 and about 9.0 microns, and an LD Dv(90) between about 15 and about 35 microns, with the aqueous suspensions further including a surfactant, a polyvinylpyrrolidone, and a sugar alcohol, and a water-soluble excipient. The water-soluble excipient can be an aryl-Ci-6alk-OH, a Ci-6alkyl-OH, a buffering salt, a polysorbate, a polyalkylene glycol, a Ci-i2alkylene glycol, a phosphatidylcholine, or a combination thereof.
Inventors:
Chen, Feng-Jin
Krill, Stephen, El.
Schmeiss, llama, abu
Heppner, Adrian
Wescott, Charles
Jasukawski, Tara
Joyce, Michael
Krill, Stephen, El.
Schmeiss, llama, abu
Heppner, Adrian
Wescott, Charles
Jasukawski, Tara
Joyce, Michael
Application Number:
JP2020524855A
Publication Date:
February 10, 2023
Filing Date:
November 08, 2018
Export Citation:
Assignee:
Eagle Pharmaceuticals, Inc.
International Classes:
A61K31/565; A61K9/10; A61K31/519; A61K47/02; A61K47/10; A61K47/12; A61K47/18; A61K47/24; A61K47/26; A61K47/32; A61P15/00; A61P35/00; A61P35/04
Domestic Patent References:
| JP2019516789A | ||||
| JP2015521207A | ||||
| JP2004534093A | ||||
| JP2013537219A | ||||
| JP2003533467A |
Foreign References:
| WO2013153559A1 |
Attorney, Agent or Firm:
Taro Yaguchi
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