Title:
FUSED PENTACYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY
Document Type and Number:
Japanese Patent JP2022116233
Kind Code:
A
Abstract:
To provide potent modulators of human TNFα activity.SOLUTION: The invention provides a compound of formula (I) in the figure or a pharmaceutically acceptable salt thereof. In the formula, X represents N or C-F; R1 represents hydrogen or methyl; R2 represents hydrogen, methyl or trifluoromethyl; and R3 represents hydrogen, cyano, hydroxy or hydroxymethyl.SELECTED DRAWING: None
Inventors:
DANIEL CHRISTOPHER BROOKINGS
TERESA DE HARO GARCIA
FORICHER YANN
HELEN TRACEY HORSLEY
MARTIN CLIVE HUTCHINGS
JAMES ANDREW JOHNSON
MACCOSS MALCOLM
XUAN MENG YANG
ZHU ZHAONING
TERESA DE HARO GARCIA
FORICHER YANN
HELEN TRACEY HORSLEY
MARTIN CLIVE HUTCHINGS
JAMES ANDREW JOHNSON
MACCOSS MALCOLM
XUAN MENG YANG
ZHU ZHAONING
Application Number:
JP2022088172A
Publication Date:
August 09, 2022
Filing Date:
May 31, 2022
Export Citation:
Assignee:
UCB BIOPHARMA SPRL
SANOFI SA
SANOFI SA
International Classes:
C07D487/18; A61K31/55; A61K45/00; A61P3/00; A61P9/00; A61P25/00; A61P25/04; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P37/06; A61P43/00
Attorney, Agent or Firm:
Asamura patent office
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