FUSED RING 4-OXOPYRIMIDINE DERIVATIVE

Japanese Patent JP2008156358

A

To provide a therapeutic agent having antagonistic activity against a histamine H3 receptor or inverse agonistic activity against a histamine H3 receptor and is effective for treating metabolic diseases, circulatory diseases or neurotic diseases.

The therapeutic agent contains a compound expressed by formula (I) or its pharmaceutically permissible salt as an effective ingredient. In the formula, Ar expresses a divalent group derived by removing 2 hydrogen atoms from benzene or the like; X1 expresses N, S or O; R1 expresses a 5-6 membered heteroaryl group or the like; A-ring expresses a 5-6 membered heteroaryl ring or the like; R2 and R3 express each an amino group or the like; -X2 expresses a group expressing an aminoalkyl group or the like.

NAGASE TAKESHI
SATO NAGAAKI
KANETANI AKIO
TOKITA SHIGERU

JP2007335972A

July 10, 2008

December 27, 2007

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BANYU PHARMA CO LTD

A61K31/395; A61K31/46; A61K31/4725; A61K31/517; A61K31/519; A61K31/55; A61K45/06; A61P1/16; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P3/12; A61P5/00; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P13/12; A61P19/06; A61P25/00; A61P25/02; A61P25/08; A61P25/10; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/32; A61P25/36; A61P43/00; C07D217/24; C07D239/70; C07D239/91; C07D401/04; C07D401/12; C07D403/04; C07D403/12; C07D471/04; C07D487/08; C07D239/90; C07D451/02

JPS5334784A	1978-03-31
JPS5665877A	1981-06-03
JPS5657768A	1981-05-20
JPS57118570A	1982-07-23
JPS5651461A	1981-05-09

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