Title:
融合ペプチド治療用組成物
Document Type and Number:
Japanese Patent JP5395664
Kind Code:
B2
Abstract:
Therapeutic compositions containing fusion proteins (FPs) including elastin-like peptides (ELPs) and peptide active therapeutic agents, and methods of making and using such compositions and fusion proteins. Therapeutic compositions of such type enable improved efficacy of the peptide active therapeutic agent to be achieved, in relation to the peptide active therapeutic agent alone. Enhanced efficacy of the peptide active therapeutic agent in the therapeutic composition may include improved solubility, bioavailability, bio-unavailability, half-life, etc., as compared to corresponding compositions containing the same peptide active therapeutic agent without associated ELPs.
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Inventors:
Chirkoty, Ashtosh
Application Number:
JP2009527565A
Publication Date:
January 22, 2014
Filing Date:
September 06, 2007
Export Citation:
Assignee:
Phase Bio Pharmaceuticals, Incorporated
International Classes:
A61K38/22; A61K38/17; A61K47/42; A61K47/48; A61P43/00; C07K19/00; C12N15/09
Domestic Patent References:
| JP2006503588A | ||||
| JP2004528014A |
Foreign References:
| WO1999038984A1 | ||||
| US6852834 | ||||
| WO2006110292A1 | ||||
| WO2006041493A1 | ||||
| US20050255554 | ||||
| WO2005000892A1 |
Other References:
MEYER,NATURE BIOTECHNOLOGY,1999年11月,V17,P1112-1115
MEYER,BIOTECHNOLOGY PROGRESS,2001年,V17 N4,P720-728
CHOW,BIOTECHNOLOGY PROGRESS,2006年,V22 N3,P2-20
MEYER,BIOTECHNOLOGY PROGRESS,2001年,V17 N4,P720-728
CHOW,BIOTECHNOLOGY PROGRESS,2006年,V22 N3,P2-20
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toshifumi Onuki
Toshifumi Onuki