Title:
アミロイドベータペプチドを分解できる融合タンパク質
Document Type and Number:
Japanese Patent JP2010522559
Kind Code:
A
Abstract:
The present invention relates fusion proteins and their use in enzymatic treatment of Alzheimer's disease patients. Said fusion protein has the formula M-A, capable of degrading amyloid beta peptide at one or more cleavage sites in its amino acid sequence, wherein M is a protein component that prolongs the half-life of the fusion protein, and A is a protein component that cleaves the amyloid beta peptide.
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Inventors:
Christine andition
Pell-Ola Freskgod
Pell-Ola Freskgod
Application Number:
JP2010500877A
Publication Date:
July 08, 2010
Filing Date:
March 27, 2008
Export Citation:
Assignee:
ASTRAZENECA AKTIEBOLAG
International Classes:
C12N9/50; A61K38/00; A61P25/00; A61P25/16; A61P25/28; A61P43/00; C07K16/18; C07K19/00; C12N15/09
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Masayuki Nakagawa
Yasushi Ochiai
Takuji Yamada
Mitsutaka Iwasaki
Masayuki Nakagawa
Yasushi Ochiai