Title:
ヒトＬｅｆｔｙ Ａタンパク質変異体を含む融合タンパク質及びその用途
Document Type and Number:
Japanese Patent JP7355828
Kind Code:
B2
Abstract:
The present invention relates to a human Lefty A protein variant with improved productivity and stability, a fusion protein comprising the protein variant, and a composition for preventing and/or treating neuromuscular disease comprising the protein variant or the fusion protein. According to the present invention, a human Lefty A protein variant and a fusion protein comprising the variant are constructed, which have better stability than naturally occurring human Lefty A protein, and thus are expressed at high levels and produced in high yield in animal cells. In addition, administration of the constructed human Lefty A protein variant or fusion protein can restore the nerve and motor functions of nerve disease model animals. Accordingly, the use of the human Lefty A protein variant or fusion protein can effectively prevent or treat various nerve diseases and muscle diseases.
Inventors:
Jung Seung Young
Lee Kyung Woo
Munsungi
Kang Sung Joon
Choi Byung Ok
Kakukon
Chang Jung Wook
Kim Jung Hyun
Lee Kyung Woo
Munsungi
Kang Sung Joon
Choi Byung Ok
Kakukon
Chang Jung Wook
Kim Jung Hyun
Application Number:
JP2021536331A
Publication Date:
October 03, 2023
Filing Date:
December 17, 2019
Export Citation:
Assignee:
CHONG KUN DANG PHARMACEUTICAL CORP.
SAMSUNG LIFE PUBLIC WELFARE FOUNDATION
SAMSUNG LIFE PUBLIC WELFARE FOUNDATION
International Classes:
C07K14/495; A61K38/18; A61K47/64; A61P21/00; A61P21/02; A61P25/02; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/19; C12N15/63; C12P21/02
Domestic Patent References:
| JP2009502121A |
Other References:
The journal of biological chemistry,2001年,Vol.276,p.21387-21396
Attorney, Agent or Firm:
Kenjiro Yamaguchi