抗発作治療用のGABA及びL-グルタミン酸類縁体

Title:

抗発作治療用のGABA及びL-グルタミン酸類縁体

Document Type and Number:

Japanese Patent JP3856816

Kind Code:

B2

Abstract:

A compound of formula (I) wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are also disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are further disclosed.

Inventors:

Silverman Richard Bee
Andrskie Wik Liszard
Yuen Po Wai
Sovier Ray Dennis Martin
Franklin Lloyd Charles
Shwind mark allen

Application Number:

JP50380794A

Publication Date:

December 13, 2006

Filing Date:

May 18, 1993

Export Citation:

Click for automatic bibliography generation Help

Assignee:

Northwestern University

International Classes:

A61P9/10; A61K31/195; C07C227/12; A61K31/197; A61P25/00; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/28; C07B53/00; C07B61/00; C07C53/42; C07C69/34; C07C69/347; C07C69/40; C07C69/675; C07C69/96; C07C227/06; C07C227/32; C07C229/00; C07C229/06; C07C229/08; C07C229/10; C07C229/24; C07C229/36; C07C247/12; C07C309/30; C07C309/73; C07C317/44; C07D263/22; C07D263/26

Domestic Patent References:

JP4523324B1
JP4538809B1
JP393759A

Other References:

Journal of Medicinal Chemistry, 1991, Vol.34, No.7
J.Chem.Soc.Perkin Trans. I, 1986, Vol.11, p1865-18
The Journal of Biological Chemistry, Vol.265, No36
J.Org.Chem., 1981, Vol.46, p1032-1035
Synthesis, 1989, Vol.12, p953-955
Tetrahedron, 1990, Vol.46, No.7, p2511-2524
J.Org.Chem., 1990, Vol.55, p3088-3097
Journal of Medicinal Chemistry, 1965, Vol.8, No.4

Attorney, Agent or Firm:

Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri

Previous Patent: メラノコルチン−４受容体アゴニストとしてのアシル化スピロピペリジン�...

Next Patent: 金属触媒と漂白剤とポリアミンＮ‐オキシド重合体とを含有する染料移動�...