Title:
GAMMA-GLUTAMYL-P-AZO-ANILIDE
Document Type and Number:
Japanese Patent JPS5697260
Kind Code:
A
Abstract:
NEW MATERIAL:γ-Glutamyl-p-azo-anilide of the formula (R is substituted aromatic group).
EXAMPLE: γ-Glutamyl-p-(4-sulfophenylazo)anilide.
USE: A substrate for measuring the activity of γ-glutamyl transpeptidase having good water-solubility without carcinogenicity. The substrate is capable of determining the orange color of liberated p-aminophenyl azo compound directly and scarcely affected by a serum of patients with icterus on the blank.
PROCESS: N-Phthalyl-γ-glutamic acid anhydride is reacted with a p-aminophenylazo compound to give N-phthalyl-γ-glutamyl-p-azo-anilide, which is then reacted with hydrazine to afford the compound of the formula.
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Inventors:
INAMOTO KANEMASA
MINAMI TAKAHISA
YODA KENTAROU
MINAMI TAKAHISA
YODA KENTAROU
Application Number:
JP73080A
Publication Date:
August 05, 1981
Filing Date:
January 07, 1980
Export Citation:
Assignee:
TOYO BOSEKI
International Classes:
C12Q1/48; C07C67/00; C07C241/00; C07C245/08; C07C245/10; (IPC1-7): C07C107/04; C12Q1/48