オニノヤガラ多糖硫酸化誘導体、その製造方法及びその用途

Japanese Patent JP5513510

B2

The present invention discloses a sulfated derivative of polysaccharide extracted from gastrodia elata BL., the preparation method thereof and the use thereof in preparing antineoplastic medicaments, wherein, the gastrodia elata polysaccharide has the following structure: ± - D - GLc �¢ p - 1 [ †’ 4 - ± - D - Glc �¢ p - ( 1 ] x †“ 6 - { [ †’ 4 ) - ± - D - Glc �¢ p - ( 1 ] y †’ 4 - ± - D - Glc �¢ p - ( 1 †’ } n - wherein, x and y are each an integer, and x + y = 16, "n" is and integer, and the mean molecular weight of the polysaccharide from gastrodia elata is estimated as 2.8 x 10 5 , the specific rotation of the polysaccharide is +95° in a 0.5 mg/mL aqueous solution thereof; the sulfated position is mainly at 6-hydroxy of the gastrodia elata polysaccharide, with mean molecular weight of 6.5 × 10 4 and a specific rotation of +150.0° in a 0.5 mg/mL aqueous solution thereof. In vivo and in vitro experiments indicate that the sulfated derivative of gastrodia elata polysaccharide can inhibit the tumor growth by suppressing the expression ofi Id1 to inhibit angiogenesis, and therefore has an obvious antitumor activity, and shows almost nontoxicity to endothelial cells, thereby having a good prospect of being developed into antineoplastic medicaments.

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Din, Kang
Kiu, Hong

JP2011528161A

June 04, 2014

September 21, 2009

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SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

A61K31/737; A61P35/00; C08B37/00; A61K36/18

Hong Qiu et al,Carbohydrate Research,2007年,Vol.342,pp2230-2236

Atsushi Nakajima
Kato Kazunori
Katsuichi Nishimoto

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