Title:
ゲムシタビン誘導体ナノ粒子
Document Type and Number:
Japanese Patent JP4927726
Kind Code:
B2
Abstract:
2',2'-Difluoro-2'-deoxycytidine derivatives (I) are new. 2',2'-Difluoro-2'-deoxycytidine derivatives of formula (I) are new. R 1-R 3 each : hydrogen or hydrocarbyl acyl of at least 18C with a conformation that imparts the capacity for (I) to adapt a compacted form in polar solvent, provided at least one is other than hydrogen. Independent claims are also included for the following: (1) nanoparticles (NP) of (I); (2) method for preparing NP; and (3) use of squalenic acid (II), or its derivatives, for formulating at least one polar active agent of molecular weight over 100 as nanoparticles. [Image] ACTIVITY : Cytostatic; Virucide. MECHANISM OF ACTION : (I) is converted intracellularly into its triphosphate and when this is incorporated into replicating DNA, elongation is stopped, resulting in cell death.
Inventors:
Barbara Stella
Ruigi Kattel
Flavio Rocco
Patrick Kvlieu
Jack-Michel Renoir
Veronique Rossio
Ruigi Kattel
Flavio Rocco
Patrick Kvlieu
Jack-Michel Renoir
Veronique Rossio
Application Number:
JP2007518660A
Publication Date:
May 09, 2012
Filing Date:
June 23, 2005
Export Citation:
Assignee:
Center National de la Recherche Scientific
Universite Paris-Sud
Barbara Stella
Ruigi Kattel
Flavio Rocco
Universite Paris-Sud
Barbara Stella
Ruigi Kattel
Flavio Rocco
International Classes:
C07H19/073; A61K9/14; A61K31/7068; A61K47/48; A61P31/12; A61P35/00
Domestic Patent References:
| JP2001323002A | 2001-11-20 | |||
| JP2001509160A | 2001-07-10 |
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro