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Patent Searching and Data


Title:
GENE TRANSFER AGENT, NUCLEIC ACID COMPLEX AND METHOD FOR PRODUCING THE SAME
Document Type and Number:
Japanese Patent JP2009275002
Kind Code:
A
Abstract:

To provide a gene transfer agent and a nucleic acid complex, excellent in gene transfer efficiency.

This gene transfer agent comprises a cationic branched type polymer becoming hydrophilic at a temperature lower than a prescribed temperature (T) which is lower than a living body temperature, and hydrophobic at a higher temperature than the prescribed temperature (T), and the cationic branched type polymer is characterized by using a compound having 3 N,N-disubstituted dithiocarbamylmethyl groups in the same molecule as an iniferter, performing the photo-irradiated living polymerization of N-isopropylacrylamide or its derivative to form its polymer block chains on the iniferter, and further performing the photo-irradiated living polymerization of a cationic monomer to form cationic polymer block chains.


Inventors:
NAKAYAMA YASUHIDE
NEMOTO YASUSHI
Application Number:
JP2008128572A
Publication Date:
November 26, 2009
Filing Date:
May 15, 2008
Export Citation:
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Assignee:
NAT CARDIOVASCULAR CT
BRIDGESTONE CORP
International Classes:
A61K48/00; A61K31/785; A61P9/00; A61P31/18; A61P35/00; C08F293/00; C12N15/09
Attorney, Agent or Firm:
Tsuyoshi Shigeno