Title:
疾患を阻止するための血管移植片の遺伝子工学処理
Document Type and Number:
Japanese Patent JP2004503216
Kind Code:
A
Abstract:
Disclosed are methods for treating a vascular graft that include introducing an effective amount of at least one nucleic acid encoding at least one agent that increases activated protein C (APC), expressing the agent in the cells; and increasing the APC sufficient to treat the blood vessel. Also provided are vascular grafts engineered to resist early and/or late graft failure.
Inventors:
Jeffrey Rade
Antony kim
Richard Sean
Antony kim
Richard Sean
Application Number:
JP2001587137A
Publication Date:
February 05, 2004
Filing Date:
May 22, 2001
Export Citation:
Assignee:
JOHNS HOPKINS UNIVERSITY
International Classes:
C12N15/09; A01K67/027; A61F2/06; A61K35/44; A61K38/17; A61K38/36; A61L27/00; A61L27/36; A61L27/50; A61L27/54; A61P37/06; C12N5/071; C12N5/10; C12N9/64; C12N15/861; C12N15/864; A61K35/12; A61K48/00; (IPC1-7): C12N15/09; A61F2/06; A61L27/00
Attorney, Agent or Firm:
Norio Saeki