To provide a new SNP, a specific combination of such SNPs and to identify a haplotype of SNP associated with myocardial infarction and related pathological conditions.
The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection. In particular, the invention relates to a specific single nucleotide polymorphism (SNP) in human genome, myocardial infarction, related pathology and their relations. Naturally occurring SNP disclosed by the specification is used as a target for design of a diagnostic reagent, development of a therapeutic agent, disease-associated analysis and chain analysis on the basis of difference in allelic frequency in a myocardial infarction patient group to a normal individual.
DEVLIN JAMES J
IAKOUBOVA OLGA
Takaaki Yasumura
Natsuki Morishita