Title:
GENETIC POLYMORPHISMS ASSOCIATED WITH VENOUS THROMBOSIS AND STATIN RESPONSE, METHODS OF DETECTION THEREOF AND USES THEREOF
Document Type and Number:
Japanese Patent JP2016063834
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide compositions and methods based on genetic polymorphisms that are associated with response to statin treatment (particularly for reducing the risk of venous thrombosis).SOLUTION: For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.SELECTED DRAWING: None
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Inventors:
LANCE BARE
DEVLIN JAMES J
FRITS R ROSENDAAL
PETER H REITSMA
IRENE D BEZEMER
DEVLIN JAMES J
FRITS R ROSENDAAL
PETER H REITSMA
IRENE D BEZEMER
Application Number:
JP2016014015A
Publication Date:
April 28, 2016
Filing Date:
January 28, 2016
Export Citation:
Assignee:
CELERA CORP
LEIDEN UNIV MEDICAL CENTER (LUMC) ACTING ON BEHALF OF ACAD HOSPITAL LEIDEN (AZL)
LEIDEN UNIV MEDICAL CENTER (LUMC) ACTING ON BEHALF OF ACAD HOSPITAL LEIDEN (AZL)
International Classes:
C12Q1/68; A61K31/22; A61K31/366; A61K31/37; A61K31/397; A61K31/40; A61K31/404; A61K31/4422; A61K31/4439; A61K31/45; A61K31/455; A61K31/505; A61K31/5377; A61K45/00; A61K45/06; A61P3/06; A61P7/02; A61P43/00; C12M1/00; C12M1/34; C12N15/09; C12Q1/04
Foreign References:
| WO2009151691A2 | 2009-12-17 |
Other References:
RAMCHARAN, A. S. ET AL.: "HMG-CoA reductase inhibitors, other lipid-lowering medication, antiplatelet therapy, and the risk o", J. THROMB. HAEMOST., vol. Vol. 7, JPN6016017271, 2009, pages pp. 514-520
SORENSEN, H. T. ET AL.: "Arterial cardiovascular events, statins, low-dose aspirin and subsequent risk of venous thromboembo", J. THROMB. HAEMOST., vol. Vol. 7, JPN6016017273, 2009, pages pp. 521-528
DOGGEN, C. J. ET AL.: "HMG CoA reductase inhibitors and the risk of venous thrombosis among postmenopausal women", J. THROMB. HAEMOST., vol. Vol. 2, JPN6016017274, 2004, pages pp. 700-701
SORENSEN, H. T. ET AL.: "Arterial cardiovascular events, statins, low-dose aspirin and subsequent risk of venous thromboembo", J. THROMB. HAEMOST., vol. Vol. 7, JPN6016017273, 2009, pages pp. 521-528
DOGGEN, C. J. ET AL.: "HMG CoA reductase inhibitors and the risk of venous thrombosis among postmenopausal women", J. THROMB. HAEMOST., vol. Vol. 2, JPN6016017274, 2004, pages pp. 700-701
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita
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