Title:
等比体積の形態変換
Document Type and Number:
Japanese Patent JP2007529475
Kind Code:
A
Abstract:
A method of generating an isosteric structure of a polypeptide at least partially containing D-amino acids from 3D-coordinates and sequence information of an L-configurated precursor having an N-terminal amino group or substituted amino group, a C-terminal carboxy group or a carboxy derivative, a backbone and L-amino acid side chains, and comprising the steps of-at least partially replacing backbone CO groups with NH groups and vice versa,-while keeping the 3D-coordinates of the precursors L-amino acid side chains, the N-terminal amino group or substituted amino group and the C-terminal carboxy group or carboxy derivative fixed.
Inventors:
Frank Hans Georg
Knorr Karsten
Hubbard Wood
Lupka Andreas
Knorr Karsten
Hubbard Wood
Lupka Andreas
Application Number:
JP2007503353A
Publication Date:
October 25, 2007
Filing Date:
March 17, 2005
Export Citation:
Assignee:
Applagen Gesellschaft Mitt Beschlenktel Haftung
International Classes:
C07K1/02; A61K8/64; A61K38/00; A61K39/00; C07K1/107; C07K1/20; C07K1/22; C07K7/02; C07K7/08; C07K14/00
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes
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