Title:
グレリン-担体複合体
Document Type and Number:
Japanese Patent JP2006504653
Kind Code:
A
Abstract:
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a ghrelin or ghrelin-derived peptide-array. More specifically, the invention provides a composition comprising a virus-like particle and at least one ghrelin or a ghrelin-derived peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of obesity and other disease associated with increased food-uptake or increased body weight and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
Inventors:
Bachmann, Martin, F.
Fluria, Alma
Fluria, Alma
Application Number:
JP2004522507A
Publication Date:
February 09, 2006
Filing Date:
July 18, 2003
Export Citation:
Assignee:
Sights Biotechnology AG
International Classes:
A61K39/00; A61K31/385; A61K38/04; A61K38/25; A61K38/27; A61K47/18; A61K47/42; A61K47/48; A61P3/04; C07K14/01; C07K14/02; C07K14/60; C12N7/00; C07K14/47; C12N15/09
Foreign References:
| WO2000032227A2 | 2000-06-08 | |||
| WO2002056905A2 | 2002-07-25 | |||
| WO2003040164A2 | 2003-05-15 | |||
| WO2003039225A2 | 2003-05-15 |
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori