イチョウジテルペンラクトン組成物

Japanese Patent JP6976446

B2

The present invention relates to a ginkgo diterpene lactone composition. The composition has the effect of improving a depressive state; the composition can prolong a tail flick interval time and a swimming interval time of a mouse to different degrees and can also increase the frequency of escaping from electric shock to different degrees; moreover, the additional addition of a certain amount of ginkgolide C, ginkgolide J, and ginkgolide L greatly enhances the effect of improving the depressive state. Furthermore, in the present invention, it is further proved through experiments that after the provision of the ginkgo diterpene lactone composition, indexes, such as SOD, MDA, GSH, and TAC, can be improved to different degrees, for example, after the addition of a certain amount of ginkgolide C, ginkgolide J, and ginkgolide L, the improving effect gets more obvious, the oxidative stress level can be better improved, and the oxidative damage can be relieved.

Xiao way
Jou Only
Chao Joyu
Chang Shiou Juyen
Kan Xiao Dong
Wang Young Shan
Huhanfei
Wu Yun
One Jen Jung
Jean Chen Fong

JP2020536587A

December 08, 2021

November 13, 2018

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JIANGSU KANION PHARMACEUTICAL CO.,LTD.

A61K31/365; A61K9/08; A61K47/02; A61K47/18; A61P25/24; A61P39/06; A61P43/00

CN1977840A

SHAO, F., et al.,European Journal of Clinical Pharmacology,2017年01月,Vol.73, No.5,pp.537-546.
MA, S., et al.,Life Sciences,2014年,Vol.114, No.2,pp.93-101.

Iseki Katsumori
Shuhei Kaneko
Wataru Onishi

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