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Title:
GLAUCOMA-TREATING AGENT AND INTRAOCULAR PRESSURELOWERING AGENT
Document Type and Number:
Japanese Patent JPH0820531
Kind Code:
A
Abstract:

PURPOSE: To obtain the glaucoma-treating agent and the intraocular pressure- lowering agent each containing an aminoalkoxybibenzyl compound or its salt as an active ingredient, and useful for preventing and treating the glaucoma, hypertension, etc.

CONSTITUTION: The glaucoma-treating agent and the intraocular pressure- lowering agent each contains a compound of formula I [R1 is H, halogen, 1-5C alkoxy, 2-6C dialkylamino; R2 is H, halogen, 1-5C alkoxy; R3 is H, OH, -O-(CH2)n-COOH (n is 1-5),-O-CO-(CH2)l-COOH (l is 1-3); R4 is group of formula II (R5,R6 are H, 1-8C alkyl); m is 0-5] or its salt, e.g. (±)-1-[0-[2-(mmethoxyphenyl)ethyl)phenoxy]-3-(dimethylamino)-2-propyl hydrogen succinate hydrochloride, as an active ingredient. The dose of the compound of formula I is generally 0.5-50mg/kg body weight/day, usually 1-30mg/kg body weight/day, and is particularly effective for herpertensive glaucoma.


Inventors:
MANO TOMIYA
Application Number:
JP15450494A
Publication Date:
January 23, 1996
Filing Date:
July 06, 1994
Export Citation:
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Assignee:
MITSUBISHI CHEM CORP
International Classes:
A61K9/06; A61K9/08; A61K31/135; A61K31/138; A61K31/19; A61K31/22; C07D295/08; A61K31/225; A61P27/02; A61P27/06; (IPC1-7): A61K31/135; A61K9/06; A61K9/08; A61K31/19; A61K31/22
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)



 
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