Title:
グルカゴン／ＧＬＰ−１受容体コアゴニスト
Document Type and Number:
Japanese Patent JP5740428
Kind Code:
B2
Abstract:
Modified glucagon peptides are disclosed having enhanced potency at the glucagon receptor relative to native glucagon. Further modification of the glucagon peptides by forming intramolecular bridges or the substitution of the terminal carboxylic acid with an amide group produces peptides exhibiting glucagon/GLP-1 receptor co-agonist activity. The solubility and stability of these high potency glucagon analogs can be further improved by modification of the polypeptides by pegylation, acylation, alkylation, substitution of carboxy terminal amino acids, C-terminal truncation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 26 (GPSSGAPPPS), SEQ ID NO: 27 (KRNRNNIA) and SEQ ID NO: 28 (KRNR).
Inventors:
Dimarchi, Richard Dee.
Smiley, David Elle.
Day, Jonathan
Bianchi, Elisabetta
Pessi, Antonello
Smiley, David Elle.
Day, Jonathan
Bianchi, Elisabetta
Pessi, Antonello
Application Number:
JP2013078799A
Publication Date:
June 24, 2015
Filing Date:
April 04, 2013
Export Citation:
Assignee:
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti SRL
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti SRL
International Classes:
C07K14/605; A61K38/26; A61P3/04; A61P3/06; A61P3/10
Domestic Patent References:
| JP2005508639A |
Other References:
GELFANOV VASILY M,UNDERSTANDING BIOLOGY USING PEPTIDES,SPRINGER,2005年 6月23日,P763-764
J. Biol. Chem.,1998年 4月24日,Vol.273, No.17,pp.10308-10312
Biochemistry,1986年 4月 8日,Vol.25, No.7,pp.1650-1656
Mol. Med.,2002年 5月,Vol.8, No.5,pp.251-262
J. Biol. Chem.,1998年 4月24日,Vol.273, No.17,pp.10308-10312
Biochemistry,1986年 4月 8日,Vol.25, No.7,pp.1650-1656
Mol. Med.,2002年 5月,Vol.8, No.5,pp.251-262
Attorney, Agent or Firm:
Isshiki International Patent Service Corporation