グルカゴン抑制剤、グルカゴン抑制用組成物およびグルカゴン抑制用食品組成物

Title:

グルカゴン抑制剤、グルカゴン抑制用組成物およびグルカゴン抑制用食品組成物

Document Type and Number:

Japanese Patent JP7083420

Kind Code:

B2

Abstract:

To provide a novel pharmaceutical agent that acts to inhibit glucagon.SOLUTION: The inventors discovered that after leptin receptor deficient model mice were given free access to feed containing arctigenin for 9 weeks, the blood glucagon concentration measured in the mice was lower in comparison to the blood glucagon concentration of a control group. Furthermore, it was discovered that in the mice administered with arctigenin, the expression level of downstream genes promoted by glucagon including FOXO1, PGC1α, PEPCK, AND G6Pase was also lower than a control group. The present invention provides a glucagon inhibitor containing arctigenin and/or arctiin as active ingredients.SELECTED DRAWING: Figure 1

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Inventors:

Satoshi Inamashi
Shinpei Watanabe
Mitsuhiro Watanabe

Application Number:

JP2021070134A

Publication Date:

June 10, 2022

Filing Date:

April 19, 2021

Export Citation:

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Assignee:

Kracie Holdings, Ltd.

International Classes:

A61K31/365; A23L33/105; A61K31/7048; A61K36/28; A61K36/634; A61P3/08; A61P35/00

Domestic Patent References:

JP2008297209A
JP2010503712A

Other References:

Diabetologia,2012年,55,pp.1469-1481
Acta Pharmacologica Sinica,2014年,35,pp.1274-1284

Attorney, Agent or Firm:

Reiji Aihara
Rio Moriwaki

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