Title:
グルカンベースのワクチン
Document Type and Number:
Japanese Patent JP5110767
Kind Code:
B2
Abstract:
Anti-glucan antibodies have been found to be protective against systemic fungal infection with C.albicans, but the protective efficacy can be inhibited by blocking antibodies. The invention provides an immunogenic composition comprising a glucan and a pharmaceutically acceptable carrier, characterised in that, when administered to a mammalian recipient, the composition elicits protective anti-glucan antibodies but does not elicit antibodies which inhibit the protective efficacy of the anti-glucan antibodies. The glucan may be presented on the surface of a protease-treated microbial cell or may be presented as a protein-glucan conjugate. Anti-glucan-antibodies show broad spectrum microbicidal activity. ²-glucans are preferred, particularly those containing one or more ²-1,6 linkages.
Inventors:
Poronelli, Luciano
Cassone, Antonio
Cassone, Antonio
Application Number:
JP2004505087A
Publication Date:
December 26, 2012
Filing Date:
May 15, 2003
Export Citation:
Assignee:
Poronelli, Luciano
Cassone, Antonio
Cassone, Antonio
International Classes:
A61K31/716; C12N15/09; A61K31/7088; A61K35/76; A61K36/06; A61K38/00; A61K39/00; A61K39/05; A61K39/09; A61K39/13; A61K39/145; A61K39/155; A61K39/205; A61K39/29; A61K39/385; A61K39/39; A61K39/395; A61K45/00; A61P31/00; A61P31/04; A61P31/06; A61P31/10; A61P33/02; A61P33/08; A61P43/00; C07K14/00; C07K14/37; C07K16/14; C12N1/14; C12R1/725
Domestic Patent References:
| JP61118320A | ||||
| JP9309842A | ||||
| JP11501691A |
Foreign References:
| US5322841 | ||||
| US6309642 |
Other References:
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TOKUNAKA K,INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY,2000年 5月,V22 N5,P383-394
Carbohydrate Polymers,2001年,Vol.44,p.339-349
Microbiol.Immunol.,1993年,Vol.37, No.2,p.129-133
FEMS Microbiol.Lett.,2001年,Vol.197,p.179-186
Macromol.Symposia,1995年,Vol.99,p.187-200
ROSS G D,IMMUNOPHARMACOLOGY,1999年 5月,V42 N1-3,P61-74
Antimicro.Agents Chemother.,1998年,Vol.42, No.3,p.545-549
Eur.J.Biochem.,1997年,Vol.246,p.320-327
Biotechnol.Appl.Biochem.,2001年,Vol.33,p.91-98
Proc.Natl.Acad.Sci.USA,1990年,Vol.87,p.1347-1351
Carbohydrate Res.,1999年,Vol.316,p.161-172
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi