Title:
グルココルチコイド受容体、AP-1、および/またはNF-κB活性の調節剤、およびその使用
Document Type and Number:
Japanese Patent JP2010500376
Kind Code:
A
Abstract:
Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including inflammatory and immune diseases, having the structure of formula (I): an enantiomer, diastereomer, or tautomer thereof, or a prodrug ester thereof, or a pharmaceutically-acceptable salt thereof, in which: Z is heterocyclo or heteroaryl; A is a 5- to 8-membered carbocyclic ring or a 5- to 8-membered heterocyclic ring; B is a cycloalkyl, cycloalkenyl, aryl, heterocyclo, or heteroaryl ring, wherein each ring is fused to the A ring on adjacent atoms and optionally substituted by one to four groups which are the same or different and are independently selected from R5, R6, R7, and R8; J1, J2, and J3 are at each occurrence the same or different and are independently -A1QA2-; Q is a bond, O, S, S(O), or S(O)2; A1 and A2 are the same or different and are at each occurrence independently selected from a bond, C1-3alkylene, substituted C1-3alkylene, C2-4alkenylene, and substituted C2-4alkenylene, provided that A1 and A2 are chosen so that ring A is a 5- to 8-membered carbocyclic or heterocyclic ring; R1 to R11 are as defined herein. Also provided are pharmaceutical compositions and methods of treating inflammatory- or immune-associated diseases and obesity and diabetes employing said compounds.
Inventors:
David S. Weinstein
Gon Hua
Jinwoo Duan
T. G. Murari Dar
Binway Bella Yang
Pin chain
Bin Jiang
Arthur MP P Dwayco
Gon Hua
Jinwoo Duan
T. G. Murari Dar
Binway Bella Yang
Pin chain
Bin Jiang
Arthur MP P Dwayco
Application Number:
JP2009523988A
Publication Date:
January 07, 2010
Filing Date:
August 09, 2007
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07D277/20; A61K31/4178; A61K31/426; A61K31/427; A61K31/433; A61K31/436; A61K31/438; A61K31/4439; A61K31/444; A61K31/4545; A61K31/496; A61K31/506; A61K31/5377; A61K31/541; A61K31/55; A61K31/551; A61K31/553; A61P1/00; A61P3/00; A61P3/04; A61P3/10; A61P5/00; A61P7/00; A61P11/00; A61P11/06; A61P17/00; A61P19/02; A61P19/10; A61P25/00; A61P27/02; A61P27/06; A61P29/00; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D277/46; C07D277/56; C07D405/12; C07D417/10; C07D417/12; C07D417/14; C07D491/052; C07D519/00
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto