Title:
グルコキナーゼ活性化インダゾール化合物
Document Type and Number:
Japanese Patent JP2011502958
Kind Code:
A
Abstract:
The present invention aims to provide a glucokinase activator useful as a pharmaceutical agent such as an agent for the prophylaxis or treatment of diabetes, obesity and the like, and the like. A compound represented by the formula (I): wherein R1 is an optionally substituted 4- to 7-membered nitrogen-containing heterocyclic group, optionally substituted carbamoyl, or optionally substituted sulfamoyl; R2 is optionally substituted alkyl, optionally substituted alkoxy, an optionally substituted 3- to 7-membered cyclic group, —SR′, —SOR′, or —SO2R′ (R′ is a substituent); R3 is hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkoxy, —O-Cy (Cy is an optionally substituted 3- to 7-membered cyclic group which may be condensed with benzene), —SR″, —SOR″, or —SO2R″ (R″ is a substituent), or an optionally substituted 3- to 7-membered cyclic group which may be condensed with benzene; R4 is hydrogen, or optionally substituted alkyl; provided that when R3 is hydrogen, halogen, or methoxy, then R2 is not optionally substituted alkyl, or optionally substituted alkoxy; further provided that 5-[5-{[(2S)-2-amino-3-phenylpropyl]oxy}-2-(3-furyl)pyridin-3-yl]-N-pyridin-4-yl-1H-indazol-3-amine and 5-[5-{[(2S)-2-amino-3-phenylpropyl]oxy}-2-(3-furyl)pyridin-3-yl]-1-(4-methoxybenzyl)-N-pyridin-4-yl-1H-indazol-3-amine are excluded; or a salt thereof.
Inventors:
Tsuneo Yasuma
Shigekazu Sasaki
Osamu Ujikawa
Yasushi Miyamoto
Gwaltney, Stefan, Elle.
Khao, Sheldon, X.
Jennings, Andy
Shigekazu Sasaki
Osamu Ujikawa
Yasushi Miyamoto
Gwaltney, Stefan, Elle.
Khao, Sheldon, X.
Jennings, Andy
Application Number:
JP2010513226A
Publication Date:
January 27, 2011
Filing Date:
June 18, 2008
Export Citation:
Assignee:
Takeda GmbH
Takeda San Diego Inc.
Takeda San Diego Inc.
International Classes:
C07D231/56; A61K31/416; A61K31/427; A61K31/4439; A61K31/444; A61K31/4545; A61K31/496; A61K31/497; A61K31/4985; A61K31/501; A61K31/506; A61K31/5377; A61K31/5383; A61K31/541; A61P3/04; A61P3/10; A61P43/00; C07D401/04; C07D401/14; C07D403/12; C07D413/14; C07D417/12; C07D417/14; C07D491/113; C07D498/04; C07D507/02
Domestic Patent References:
| JP2010529137A | 2010-08-26 | |||
| JP2010513231A | 2010-04-30 |
Foreign References:
| WO2005085227A1 | 2005-09-15 | |||
| WO2007075847A2 | 2007-07-05 |
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Kenji Yamamoto
Murata Miyuki
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Kenji Yamamoto
Murata Miyuki