Title:
グルコキナーゼ化合物
Document Type and Number:
Japanese Patent JP3987829
Kind Code:
B2
Abstract:
The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R 1 , R 2 , R 3 , n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes.
The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).
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Inventors:
Void, scott
Colecket, Peter William Rodney
Hargreaves, Rodney Bryan
Boker, Suzanne Saxon
James, roger
Johnston, Craig
Clifford David, Jones
McKellecher, Darren
Brock, Michael Howard
Colecket, Peter William Rodney
Hargreaves, Rodney Bryan
Boker, Suzanne Saxon
James, roger
Johnston, Craig
Clifford David, Jones
McKellecher, Darren
Brock, Michael Howard
Application Number:
JP2003520733A
Publication Date:
October 10, 2007
Filing Date:
August 15, 2002
Export Citation:
Assignee:
AstraZeneca Activrag
International Classes:
C07D213/75; A61K31/165; A61K31/167; A61K31/192; A61K31/195; A61K31/341; A61K31/415; A61K31/4155; A61K31/42; A61K31/425; A61K31/426; A61K31/427; A61K31/428; A61K31/433; A61K31/44; A61K31/4402; A61K31/4436; A61K31/4439; A61K31/444; A61K31/445; A61K31/454; A61K31/455; A61K31/496; A61K31/4965; A61K31/497; A61K31/50; A61K31/501; A61K31/505; A61K31/506; A61K31/5377; A61P3/04; A61P3/06; A61P3/10; A61P43/00; C07D209/40; C07D213/76; C07D213/82; C07D213/85; C07D231/40; C07D233/48; C07D233/88; C07D237/20; C07D237/24; C07D239/42; C07D239/47; C07D241/20; C07D241/26; C07D241/28; C07D261/14; C07D263/48; C07D277/20; C07D277/46; C07D277/54; C07D277/56; C07D277/58; C07D277/82; C07D285/12; C07D285/135; C07D307/66; C07D307/68; C07D401/04; C07D403/04; C07D405/12; C07D409/12; C07D409/14; C07D413/04; C07D413/12; C07D413/14; C07D417/04; C07D417/12; C07D417/14; A61K31/404; A61K31/4168; A61K31/421
Domestic Patent References:
| JP2005500312A | ||||
| JP2004517087A | ||||
| JP2004506632A | ||||
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| JP2003531898A | ||||
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Foreign References:
| WO2001044216A1 | ||||
| WO2000058293A1 |
Other References:
Monika Mazik et al.,"Molecular recognition of carbohydrates by artificial polypyridine and polypyrimidine receptors",Angew. Chem. Int. Ed.,2000年,vol.39, no.3,p.551-554
Burkhard Koenig et al.,"Binding of Heptanedioic Acid to a Threefold Pyridine Arylamide Receptor. Enhancement of the Stability of Supramolecular Solution Structures by Multiple Binding Sites",Journal of Organic Chemistry,1995年,vol.60, no.13,p.4291-3
Monika Mazik et al.,"Molecular recognition of carbohydrates by artificial receptors: systematic studies towards recognition motifs for carbohydrates",Chemistry--A European Journal,2001年,vol.7, no.3,p.664-670
ZHANG, San-Qi et al.,"Synthesis based on affinity separation (SAS): separation of products having barbituric acid tag from untagged compounds by using hydrogen bond interaction",Synlett,2001年,no.5,p.590-596
Burkhard Koenig et al.,"Binding of Heptanedioic Acid to a Threefold Pyridine Arylamide Receptor. Enhancement of the Stability of Supramolecular Solution Structures by Multiple Binding Sites",Journal of Organic Chemistry,1995年,vol.60, no.13,p.4291-3
Monika Mazik et al.,"Molecular recognition of carbohydrates by artificial receptors: systematic studies towards recognition motifs for carbohydrates",Chemistry--A European Journal,2001年,vol.7, no.3,p.664-670
ZHANG, San-Qi et al.,"Synthesis based on affinity separation (SAS): separation of products having barbituric acid tag from untagged compounds by using hydrogen bond interaction",Synlett,2001年,no.5,p.590-596
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri