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Patent Searching and Data


Title:
GLYCOAMINOOXAZOLINES
Document Type and Number:
Japanese Patent JPH07316178
Kind Code:
A
Abstract:

PURPOSE: To obtain new compounds having excellent saccharide hydroxidase- inhibiting activity and useful as antibestics, antidiabetics, insecticides and anti- HIV agents.

CONSTITUTION: A compound of formula I (R1 is H or a saccharide residue), e.g. 2-amino-[3aR-(3aα,5β,6α,7',7αβ)]-5-(hydroxymethyl) 3a,6, 7,7a-tetrahydro-5H- pyrano[2,3-d]oxazole-6,7-diol. The compound is obtained by reacting a compound of formula II (R2 is acetyl, benzoyl, etc.) with a compound of the formula R1aNCS (R1a is an amino group protecting group or a saccharide protected with an aralkyl) in an inert solvent (preferably benzene) to afford a compound of formula III, removing R2 IN the compound of formula III, reacting the product with 2-chloro-3-ethylbenzooxazolium-tetrafluoroborate in an inert solvent (preferably nitriles) in the presence of a base (triethylamine).


Inventors:
SHIOSAKI MASAO
Application Number:
JP1994000110761
Publication Date:
December 05, 1995
Filing Date:
May 25, 1994
Export Citation:
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Assignee:
SANKYO CO
International Classes:
C12N9/99; A61K31/70; A61P3/04; A61P43/00; C07H9/06; (IPC1-7): C07H9/06
Attorney, Agent or Firm:
大野 彰夫 (外2名)