Title:
グリコーゲンシンターゼキナーゼ3のインヒビター
Document Type and Number:
Japanese Patent JP2006506383
Kind Code:
A
Abstract:
New carbocyclic compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as in the treatment of diabetes, Alzheimer's disease, other neurodegenerative disorders, such as Parkinson's disease and Huntington's disease, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.
Inventors:
Eggplant, John M.
Sabramanian, Sharadha
Wagman, Alain Es.
Sabramanian, Sharadha
Wagman, Alain Es.
Application Number:
JP2004546978A
Publication Date:
February 23, 2006
Filing Date:
October 20, 2003
Export Citation:
Assignee:
Chiron Corporation
International Classes:
C07D213/74; A61K31/155; A61K31/427; A61K31/44; A61K31/4439; A61K31/496; A61K31/4965; A61K31/5377; A61K38/28; A61K45/00; A61P3/06; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P15/08; A61P25/14; A61P25/16; A61P25/28; A61P35/00; A61P37/04; A61P43/00; C07D213/78; C07D213/85; C07D401/12
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita