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Title:
GLYCOPROTEIN COMPOSITION
Document Type and Number:
Japanese Patent JP2010248228
Kind Code:
A
Abstract:

To provide compositions comprising a glycoprotein having an Fc region.

The composition comprises a mature core carbohydrate structure lacking fucose wherein 51-100% of the glycoprotein in the composition is attached to the Fc region of the glycoprotein. The Fc region contains an amino acid sequence that differs from a native sequence of a human IgG Fc region. The composition comprises a glycoprotein having a human IgG Fc region, wherein the glycoprotein binds the FcγRIII with better affinity, or mediates antibody-dependent cell-mediated cytotoxicity (ADCC) more effectively, than the glycoprotein with a mature core carbohydrate structure including fucose attached to the Fc region of the glycoprotein. The preferred glycoprotein is an antibody or an immunoadhesin.


Inventors:
PRESTA LEONARD G
Application Number:
JP2010149920A
Publication Date:
November 04, 2010
Filing Date:
June 30, 2010
Export Citation:
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Assignee:
GENENTECH INC
International Classes:
A61K38/00; A61K39/395; C12N15/09; A61P1/04; A61P1/16; A61P3/10; A61P5/40; A61P7/04; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P29/00; A61P31/00; A61P31/04; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08; C07K16/18; C07K16/28; C07K16/32; C07K16/42; C12N5/10; C12P21/02; C12P21/08; C07K14/47
Foreign References:
WO2000061739A12000-10-19
WO2000042072A22000-07-20
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori