Title:
GNRH ANTAGONISTIC SUBSTANCE
Document Type and Number:
Japanese Patent JPS60136598
Kind Code:
A
Abstract:
Peptides which inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. Administration of an effective amount prevents ovulation of female mammalian eggs and/or the release of steroids by the gonads. The peptides have the structure: X- beta -D-2NAL-R2-D-Trp-Ser-Arg-R6-R7-Arg-Pro-R10 wherein X is hydrogen or Ac; R2 is Cl-D-Phe, F-D-Phe or C alpha Me-Cl-D-Phe; R6 is D-Tyr, beta -D-2NAL or D-Arg; R7 is Leu or N alpha Me-Leu; and R10 is Gly-NH2, NHCH2CH3 or D-Ala-NH2.
Inventors:
ROJIYAA UIRIAMU ROOSUKU
JIYAN EDOWAARU FUREDERITSUKU R
WAIRII UOOKAA BEERU JIYUNIAA
JIYAN EDOWAARU FUREDERITSUKU R
WAIRII UOOKAA BEERU JIYUNIAA
Application Number:
JP25280084A
Publication Date:
July 20, 1985
Filing Date:
November 29, 1984
Export Citation:
Assignee:
SALK INST FOR BIOLOGICAL STUDI
International Classes:
A61K38/22; A61P5/00; A61K38/04; C07K7/08; C07K7/23; C07K14/575; A61K38/00; (IPC1-7): A61K37/24; C07K7/20; C07K99/54
Attorney, Agent or Firm:
Kyozo Yuasa