Title:
移植片拒絶反応抑制剤
Document Type and Number:
Japanese Patent JP4212278
Kind Code:
B2
Abstract:
It was found that antibodies against AILIM (also known as ICOS and 8F4) and AILIM-Ig have significant therapeutic effects towards the suppression and prevention of graft rejection. Graft rejection is a serious problem associated with tissue or organ transplantation (allotransplantation or xenotransplantation), performed to treat various organ failures (liver, heart, lung, kidney, pancreas, etc.) .
Inventors:
Suzuki Seiichi
Mitsuaki Isobe
Mitsuaki Isobe
Application Number:
JP2002013189A
Publication Date:
January 21, 2009
Filing Date:
January 22, 2002
Export Citation:
Assignee:
Japan Tobacco Inc.
International Classes:
A61K38/02; A61K31/453; A61K39/395; A61K31/7105; A61K31/711; A61K38/00; A61K45/00; A61P37/06; C07K16/28
Domestic Patent References:
| JP2000154151A | ||||
| JP11228442A | ||||
| JP3871503B2 |
Foreign References:
| WO1998038216A1 | ||||
| WO1998019706A1 | ||||
| WO1995033770A1 | ||||
| WO2000046240A1 | ||||
| WO1999015553A1 |
Other References:
Anna Tafuri et. al.,ICOS is essential for effective T-helper-cell responses,Nature,2001年 1月,Vol.409,p.105-109
Steven K. Yoshinaga et. al.,T-cell co-stimulation through B7RP-1 and ICOS,Nature,1999年,Vol.402,p.827-832
Andreas Hutloff,ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28,Nature,1999年,Vol.397,p.263-266
Steven K. Yoshinaga et. al.,T-cell co-stimulation through B7RP-1 and ICOS,Nature,1999年,Vol.402,p.827-832
Andreas Hutloff,ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28,Nature,1999年,Vol.397,p.263-266
Attorney, Agent or Firm:
Hatsushi Shimizu
Teruo Daito
Teruo Daito
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