GROUP OF BASE SEQUENCE FOR HLA-DR TYPING AND HLA-DR TYPING METHOD USING THE SAME BASE SEQUENCE

Title:

GROUP OF BASE SEQUENCE FOR HLA-DR TYPING AND HLA-DR TYPING METHOD USING THE SAME BASE SEQUENCE

Document Type and Number:

Japanese Patent JPH0690757

Kind Code:

A

Abstract:

PURPOSE: To provide the subject new oligonucleotide probe useful for gene-typing of HLA-DR antigen.

CONSTITUTION: An oligonucleotide probe for an oligonucleotide nucelic acid base sequence, e.g. A3 (GCCGGGTGGA CAACTACT), F10 (TTATGGACGC GTCTTTCCA), A1416 (AGCGCACGTT CTCCTCCTG), K1406 (GCACGTTCTC CTCCTGGTT), F30 (GCTCGTCTTC CAGGAAGTC) or F44 (GAGCAGAAGC GGGCCGCG) capable of specifically crossing with a base sequence of an antigen- decision part of DR antigen, e.g. OA3, OF10, OA1416, OK1406, OF30 or OF44. This probe can be obtained by synthesis using an automated DNA synthesizer made by Applied Biosystem Co. and subsequent purification according to the denaturated polyacrylamide gel electrophoresis method.

Inventors:

OBATA BUNYA
KASHIWAGI NOBORU
ABE AKIO
MIYAKOSHI TERUICHI

Application Number:

JP22443292A

Publication Date:

April 05, 1994

Filing Date:

August 24, 1992

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Assignee:

KITASATO INST
MITSUI PETROCHEMICAL IND

International Classes:

C07H21/04; C12N15/09; C12N15/10; C12Q1/68; G01N33/53; (IPC1-7): C12N15/11; C07H21/04; C12N15/10; C12Q1/68; G01N33/53

Attorney, Agent or Firm:

Yusuke Hiraki (2 outside)

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