Title:
GRPR-ANTAGONISTS FOR DETECTION, DIAGNOSIS AND TREATMENT OF GRPR-POSITIVE CANCER
Document Type and Number:
Japanese Patent JP2019167365
Kind Code:
A
Abstract:
To provide probes for use in detection, imaging, diagnosis, targeting, treatment, etc. of cancers expressing the gastrin releasing peptide receptor (GRPR).SOLUTION: The invention provides a GRPR-antagonist represented by the general formula in the figure. (MC is a metal chelate, which comprises at least one (radio)metal (M) and a chelator (C) which stably binds M; S is an optional spacer covalently linked between the N-terminal of P and C; and P is a peptide derivative having a specific structure where a carboxyl terminal of a peptide comprising 7 amino acids is modified.SELECTED DRAWING: Figure 1A
Inventors:
THEODOSIA MAINA-NOCK
BERTHOLD ARTUR NOCK
MARION DE JONG HENDRIKS
BERTHOLD ARTUR NOCK
MARION DE JONG HENDRIKS
Application Number:
JP2019104379A
Publication Date:
October 03, 2019
Filing Date:
June 04, 2019
Export Citation:
Assignee:
ADVANCED ACCELERATOR APPLICATIONS USA INC
International Classes:
C07K7/06; A61K47/64; A61K51/08; A61P1/00; A61P1/18; A61P11/00; A61P13/08; A61P13/12; A61P15/00; A61P17/00; A61P25/00; A61P35/00; A61P43/00; C07F13/00
Domestic Patent References:
| JP6562838B2 | 2019-08-21 | |||
| JPH04502629A | 1992-05-14 | |||
| JP2006528644A | 2006-12-21 | |||
| JPH02250898A | 1990-10-08 |
Foreign References:
| US5620955A | 1997-04-15 | |||
| US5028692A | 1991-07-02 | |||
| US5019647A | 1991-05-28 |
Other References:
CLINICAL CANCER RESEARECH, vol. 15, no. 16, JPN6017016019, 2009, pages 5240 - 5249, ISSN: 0004512398
CHEMISTRY A EUROPEAN JOURNAL, vol. 16, JPN6017016018, 2010, pages 2115 - 2124, ISSN: 0004512399
JOURNAL OF MEDICINAL CHEMISTRY, vol. 34, JPN6017016021, 1991, pages 2102 - 2107, ISSN: 0004512400
BIOCONJUGATE CHEMISTRY, vol. 19, JPN6017016020, 2008, pages 2040 - 2048, ISSN: 0004287511
CHEMISTRY A EUROPEAN JOURNAL, vol. 16, JPN6017016018, 2010, pages 2115 - 2124, ISSN: 0004512399
JOURNAL OF MEDICINAL CHEMISTRY, vol. 34, JPN6017016021, 1991, pages 2102 - 2107, ISSN: 0004512400
BIOCONJUGATE CHEMISTRY, vol. 19, JPN6017016020, 2008, pages 2040 - 2048, ISSN: 0004287511
Attorney, Agent or Firm:
Einzel Felix-Reinhard
Junichi Maekawa
Hiroyasu Ninomiya
Ueshima
Junichi Maekawa
Hiroyasu Ninomiya
Ueshima