Title:
グアニジン誘導体及びその医薬用途
Document Type and Number:
Japanese Patent JP6927042
Kind Code:
B2
Abstract:
An object of the present invention is to provide a compound having a guanidine skeleton which inhibits the protease activity of MALT1 and exerts a therapeutic or prophylactic effect on autoimmune disease such as psoriasis or allergic disease such as atopic dermatitis. The present invention provides a guanidine derivative typified by the following formula or a pharmacologically acceptable salt thereof.
Inventors:
Yoshitaka Numajiri
Keiichi Okimura
Yuki Matsumura
Asaba Aya Nunets
Tomohide Masuda
Kazuyuki Tokumaru
Yasufumi Goto
Shigeo Fujii
Keiichi Okimura
Yuki Matsumura
Asaba Aya Nunets
Tomohide Masuda
Kazuyuki Tokumaru
Yasufumi Goto
Shigeo Fujii
Application Number:
JP2017541135A
Publication Date:
August 25, 2021
Filing Date:
July 28, 2017
Export Citation:
Assignee:
TORAY INDUSTRIES,INC.
International Classes:
C07D213/36; A61K31/4418; A61K31/443; A61K31/4436; A61K31/4439; A61P17/00; A61P17/06; A61P37/06; A61P37/08; A61P43/00; C07D213/84; C07D401/12; C07D405/12; C07D409/12; C07D417/12
Foreign References:
| WO2006042955A1 | ||||
| US3313813 | ||||
| WO2013106761A2 | ||||
| WO2017040304A1 | ||||
| WO2009065897A2 |
Other References:
PAUL, H. et al.,3-Benzyloxycarbonylaminomethyl-1,2,4-triazines from benzyloxycarbonylaminoacetamidrazone and benzils,Chemische Berichte,1968年,Vol.101, No.11,p.3696-9,ISSN: 0009-2940
XIN, B. T. et al.,Development of new Malt1 inhibitors and probes,Bioorganic & Medicinal Chemistry,2016年03月28日,Vol.24,p.3312-29,doi.org/10.1016/j.bmc.2016.03.035
XIN, B. T. et al.,Development of new Malt1 inhibitors and probes,Bioorganic & Medicinal Chemistry,2016年03月28日,Vol.24,p.3312-29,doi.org/10.1016/j.bmc.2016.03.035
Attorney, Agent or Firm:
Hiraki International Patent Office