Title:
【発明の名称】14β-H-、14-および15-エン-11β-アリール-4-エストレン
Document Type and Number:
Japanese Patent JPH06505708
Kind Code:
A
Abstract:
PCT No. PCT/EP91/02494 Sec. 371 Date Jun. 22, 1993 Sec. 102(e) Date Nov. 1, 1993 PCT Filed Dec. 21, 1991 PCT Pub. No. WO92/11278 PCT Pub. Date Jul. 9, 1992.Novel compounds of the general formula I (I) and the pharmacologically tolerable addition salts thereof with acids are described, in which either Ia) R11 represents a hydrogen atom in the beta -configuration and each of R12 and R13 represents a hydrogen atom, or Ib) R11 represents a hydrogen atom in the beta -configuration and R12 and R13 together represent a second bond, or Ic) R11 and R12 together represent a second bond and R13 represents a hydrogen atom, or Id) R11 represents a hydrogen atom in the alpha -configuration and R12 and R13 together represent a second bond, and in Ia), Ib), Ic) or Id) X represents an oxygen atom, the hydroxyimino grouping >N DIFFERENCE OH or two hydrogen atoms, R1 represents a hydrogen atom or a methyl group, R2 represents a hydroxy group, a C1-C10-alkoxy group or a C1-C10-acyloxy group, and R3 and R4 have the meanings customary for competitive progesterone antagonists specified in the description. The invention relates also to processes for the preparation of the novel compounds, to pharmaceutical compositions containing those compounds, to their use for the manufacture of medicaments, and to the novel intermediates required for the process. The novel compounds have a strong affinity for the gestagen receptor and exhibit pronounced antigestagenic and also antiglucocorticoid, antimineralocorticoid and antiandrogenic properties.
Inventors:
Schwede, Wolfgang
Ottoff, Eckhart
Nef, Gunter
Kleve, Albert
Kvaritz, Krutztsov
Mihina, horst
Furman, Ulrike
Ottoff, Eckhart
Nef, Gunter
Kleve, Albert
Kvaritz, Krutztsov
Mihina, horst
Furman, Ulrike
Application Number:
JP50140691A
Publication Date:
June 30, 1994
Filing Date:
December 21, 1991
Export Citation:
Assignee:
Schering Aktiengesellschaft
International Classes:
A61K31/565; A61K31/58; A61K31/585; A61P5/38; C07J1/00; C07J3/00; C07J5/00; C07J7/00; C07J9/00; A61K31/57; C07J17/00; C07J21/00; C07J33/00; C07J41/00; C07J43/00; (IPC1-7): C07J1/00; A61K31/57; A61K31/58; A61K31/585; C07J3/00; C07J5/00; C07J7/00; C07J21/00; C07J41/00
Attorney, Agent or Firm:
Toshio Yano (2 outside)