Title:
ＨＣＶＮＳ−３セリンプロテアーゼインヒビター
Document Type and Number:
Japanese Patent JP5795619
Kind Code:
B2
Abstract:
Methods drawn to peptidomimetic compounds which inhibit the NS3 protease of the hepatitis C virus (HCV), are described. The compounds have the formula (VI) where the variable definitions are as provided in the specification. The compounds comprise a carbocyclic P2 unit in conjunction with a novel linkage to those portions of the inhibitor more distal to the nominal cleavage site of the native substrate, which linkage reverses the orientation of peptidic bonds on the distal side relative to those proximal to the cleavage site.
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Inventors:
Author Rosenquist
Fredrick Tolstenson
Pale-Ola Johansson
Ingemar Kvarung Strem
Bertil Samuelson
Hans Valberg
Fredrick Tolstenson
Pale-Ola Johansson
Ingemar Kvarung Strem
Bertil Samuelson
Hans Valberg
Application Number:
JP2013234011A
Publication Date:
October 14, 2015
Filing Date:
November 12, 2013
Export Citation:
Assignee:
Mediville Actie Borrag
International Classes:
A61K31/47; A61K31/4709; A61P31/12; A61P43/00; C07C235/40; C07C237/04; C07C237/10; C07C247/04; C07C271/22; C07C281/02; C07C309/73; C07C311/51; C07D207/16; C07D215/233; C07D245/04; C07D401/12; C07D405/14; C07D409/14; C07D413/14; C07D417/04; C07D417/14; C07D487/04; C07K5/02; C07K5/06; C07D215/22; C07D
Domestic Patent References:
| JP2002542160A | ||||
| JP2003513891A | ||||
| JP2003526634A |
Foreign References:
| WO2005010029A1 | ||||
| WO2004002944A1 |
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Takumi Terachi
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Takumi Terachi