Title:
HIVインテグラーゼ阻害薬
Document Type and Number:
Japanese Patent JP2007528396
Kind Code:
A
Abstract:
Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: wherein Z, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
Inventors:
Moriset, Machine M
Williams, Peter Day
Wye, Jiyoung S
Fisher, Sauce Ten Yi
Lyle, Terry A
Williams, Peter Day
Wye, Jiyoung S
Fisher, Sauce Ten Yi
Lyle, Terry A
Application Number:
JP2007502875A
Publication Date:
October 11, 2007
Filing Date:
March 04, 2005
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07D471/04; A61K31/4375; A61P31/18; A61P43/00; C07D471/10; A61K31/444; A61K31/506
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura