Title:
HIVインテグラーゼ阻害薬
Document Type and Number:
Japanese Patent JP2008502741
Kind Code:
A
Abstract:
Bicyclic pyrazoles of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: wherein Z is O or N(R8); n is an integer equal to zero or 1; and R1, R2, R3, R4, R5, R6, R7 and R8 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
Inventors:
Wye, Jiyoung S
Williams, Peter Day
Langford, H. Marie
Williams, Peter Day
Langford, H. Marie
Application Number:
JP2007527822A
Publication Date:
January 31, 2008
Filing Date:
June 03, 2005
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07D487/04; A61K31/4985; A61K31/52; A61K31/5377; A61K31/551; A61K45/00; A61P31/18; A61P37/04; A61P43/00
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura