Title:
HLA-制限型B型肝炎ウィルスのCTLエピトープ
Document Type and Number:
Japanese Patent JP3738395
Kind Code:
B2
Abstract:
Cytotoxic T lymphocyte-stimulating peptides induce HLA-restricted responses to hepatitis B virus antigens. The peptides, derived from CTL epitopic regions of both HBV surface and nucleocapsid antigens, are particularly useful in the treatment and prevention of HBV infection, including the treatment of chronically infected HBV carriers. The peptides can be formulated as HBV vaccines and pharmaceutical compositions, such as lipid-containing compositions for enhancing the HLA-restricted CTL responses. The peptides are also useful in diagnostic methods, such as predicting which HBV-infected individuals are prone to developing chronic infection.
Inventors:
Vitiero, Maria A.
Chestnut, Robert W.
Chestnut, Robert W.
Application Number:
JP50466493A
Publication Date:
January 25, 2006
Filing Date:
August 26, 1992
Export Citation:
Assignee:
EpiMune, Inc.
International Classes:
C07K7/06; C12Q1/02; A61K38/10; A61K39/29; A61K39/395; A61K47/48; A61P31/12; A61P31/20; C07K7/08; C07K14/00; C07K14/02; C07K17/02; C07K17/06; C07K19/00; C12N15/09; C12N15/51; G01N33/50; A61K39/00
Other References:
Science, 1990年,248, 361-364
Attorney, Agent or Firm:
Takashi Ishida
Masatoshi Iwade
Toshio Toda
Masaya Nishiyama
Higuchi Souji
Masatoshi Iwade
Toshio Toda
Masaya Nishiyama
Higuchi Souji