HSVプライマーゼインヒビター

Japanese Patent JP3762868

B2

The invention provides compounds of the formula 1 that are active against the HSV primase enzyme:whereinR1 is hydroxy or amino;R2 is hydrogen, halo, (C1-4)alkyl or (C1-4)alkoxy; R3 is hydrogen, halo, (C1-4)alkyl, (C1-4)alkoxy, amino or azido; R4 has the same significance as R2;R5 is hydrogen or (C1-4)alkyl; and R is (C1-7)alkyl, (C3-6)cycloalkyl, {phenyl(C1-7)alkyl}, {phenyl(C1-7)alkoxy}, {{(monocyclic heterocyclo)-{(C1-7)alkoxy}}, CH(W)C(O){O-(C1-4)alkyl} wherein W is hydrogen or (C1-7)alkyl, or wherein Y is hydrogen or (C1-7)alkyl, and Z is (C1-7)alkyl, (C3-6) cycloalkyl, {(C3-6)cycloalkyl}- {(C1-7)alkyl}, phenyl(C1-7)alkyl or {{(monocyclic heterocyclo)-{(C1-7)alkyl}}, or Y and Z together with the nitrogen atom to which they are attached represent, 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl or 1-(4-methylpiperazinyl); with the provisos that (1) when R is CH(W)C(O)-{O-(C1-4)alkyl} as defined herein, then R5 is hydrogen; and (2) at least one of R2, R3 and R4 is other than hydrogen.

Simone Bruno
Riuge Michelle
Mentorup Anton

JP2000607974A

April 05, 2006

March 23, 2000

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Boehringer Ingelheim (Canada) Limited

C07C235/64; A61K31/165; C07D295/18; A61K31/167; A61K31/4402; A61K31/4453; A61K31/52; A61K31/522; A61K31/535; A61K31/7068; A61K38/17; A61K45/06; A61K48/00; A61P31/22; C07C235/00; C07C235/60; C07C235/62; C07C237/30; C07C237/38; C07C237/40; C07C237/42; C07C237/44; C07C247/18; C07D213/30; C07D213/40; C07D295/192

JP4507422A

US5258407

Minoru Nakamura
Fumiaki Otsuka
Sadao Kumakura
Shishido Kaichi
Hideto Takeuchi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Takaki Nishijima
Atsushi Hakoda

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