HUMAN IgG Fc DOMAIN VARIANTS WITH IMPROVED EFFECTOR FUNCTION

Title:

HUMAN IgG Fc DOMAIN VARIANTS WITH IMPROVED EFFECTOR FUNCTION

Document Type and Number:

Japanese Patent JP2023182640

Kind Code:

A

Abstract:

To provide human IgG Fc domain variants with improved effector function and uses thereof.SOLUTION: A polypeptide comprises an Fc variant of a human IgG1 Fc polypeptide, wherein the Fc variant (i) comprises an Alanine (A) at position 236, a Leucine (L) at position 330, and a Glutamic acid (E) at position 332, and (ii) does not comprise an Aspartic acid (D) at position 239, and wherein the numbering is according to the EU index in Kabat.SELECTED DRAWING: None

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Inventors:

JEFFREY V RAVETCH
STELIOS BOURNAZOS

Application Number:

JP2023160189A

Publication Date:

December 26, 2023

Filing Date:

September 25, 2023

Export Citation:

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Assignee:

UNIV ROCKEFELLER

International Classes:

C12N15/13; A61K31/7088; A61K35/76; A61K38/02; A61K39/395; A61K48/00; A61P29/00; A61P31/04; A61P35/00; C07K16/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/63; C12P21/08

Attorney, Agent or Firm:

IBC Ichibancho Patent Attorney Corporation

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