Title:
インフルエンザ菌感染症の予防用ワクチンとしてのインフルエンザ菌リポ多糖内部コアオリゴ糖エピトープ
Document Type and Number:
Japanese Patent JP2004506086
Kind Code:
A
Abstract:
The present invention relates to a lipopolysaccharide moiety comprising a conserved triheptosyl inner-core moiety of lipopolysaccharide substantially free of variable outer core oligosaccharide chain extension, and to vaccines obtaines therefrom which are cross-reactive for Haemophilus influenzae strains. The invention also relates to defined mutations in the biosynthetic machinery for lipopolysaccharide (LPS;) expression in Haemophilus influenzae useful to obtain the abovementioned moiety. The invention also relates to using conjugates of the LPS from the mutant strains so obtained to elicit a heterologous immune response against a wide range of disease-causing H. influenzae strains. More specifically, the invention relates to vaccines for prevention of bacterial infections comprising core lipopolysaccharide of Haemophilus influenzae.
Inventors:
James, C. Richards
Andrew, Cox
Richard, Moxon
Derek, Hood
Elk, Kay H. Shweda
Martin, Manson
Andrew, Cox
Richard, Moxon
Derek, Hood
Elk, Kay H. Shweda
Martin, Manson
Application Number:
JP2002521535A
Publication Date:
February 26, 2004
Filing Date:
August 27, 2001
Export Citation:
Assignee:
AVENTIS PASTEUR LIMITED
International Classes:
C12N15/09; A61K39/145; A61K39/395; A61P31/16; C07K16/12; C08B37/00; C12P21/08; (IPC1-7): C08B37/00; A61K39/145; A61K39/395; A61P31/16; C07K16/12; C12N15/09; C12P21/08
Foreign References:
| WO2000036419A1 | 2000-06-22 |
Attorney, Agent or Firm:
Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Yukitaka Nakamura
Konno Akio
Noritaka Yokota