HBM VARIANTS THAT MODULATE BONE MASS AND LIPID LEVELS

Japanese Patent JP2011004744

A

To provide methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5, or LRP6 in animal cells and transgenic animals, and also to provide transgenic animals expressing the HBM-like polypeptides.

There are provided nucleic acids including specific coding sequences, oligonucleotide primers, and probes; proteins, cloning vectors; expression vectors; transformed hosts; methods of developing pharmaceutical compositions; methods of identifying molecules involved in bone development; and methods of diagnosing and treating diseases involved in bone development and lipid modulation. The preferred embodiment is directed to methods for treating, diagnosing and preventing osteoporosis.

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ALLEN KRISTINA
ANISOWICZ ANTHONY
GRAHAM JAMES R
MORALES ARTURO
YAWORSKY PAUL J
LIU WEI

JP2010146427A

January 13, 2011

June 28, 2010

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OSCIENT PHARMACEUTICALS CORP
WYETH LLC

C12N15/09; A01K67/027; A61K39/395; A61K45/00; A61P3/00; A61P3/14; A61P5/14; A61P5/18; A61P19/00; A61P19/08; A61P19/10; C07K14/47; C07K14/51; C07K16/18; C07K16/22; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12N15/85; C12P21/08; C12Q1/02; C12Q1/66; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/531; G01N33/532; G01N33/566; G01N33/577; A61K35/00; A61K38/00

Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo

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