Title:
心疾患治療剤
Document Type and Number:
Japanese Patent JP5191235
Kind Code:
B2
Abstract:
The present inventors investigated the effects ofanti-IL-6 receptor antibodies on improving the condition of infarcted areas in myocardial infarction, and on suppressing left ventricular remodeling after myocardial infarction. As a result, the administration of anti-IL-6 receptor antibodies significantly suppressed the increase of MPO activity in the infarcted area and suppressed myocardial MCP-1 expression in both the infarcted area and the non-infarcted area. Furthermore, echocardiography and histological examinations revealed that cardiac hypertrophy is also suppressed.
Inventors:
Ohara
Application Number:
JP2007541050A
Publication Date:
May 08, 2013
Filing Date:
October 20, 2006
Export Citation:
Assignee:
Chugai Pharmaceutical Co., Ltd.
International Classes:
A61K39/395; A61P9/10; A61P43/00; A61K45/00
Foreign References:
| WO2005061000A1 | 2005-07-07 | |||
| WO2005037315A1 | 2005-04-28 | |||
| WO2004096273A1 | 2004-11-11 | |||
| WO2005028514A1 | 2005-03-31 | |||
| WO1998036061A2 | 1998-08-20 |
Other References:
JPN7012001134; ＤＩＮＧ，Ｗ． ｅｔ ａｌ．: 'Ｔｈｅ ｃｈａｎｇｅ ｏｆ ｐｌａｓｍａ ｉｎｔｅｒｌｅｕｋｉｎ-６ ｌｅｖｅｌ ａｎｄ ｃａｒｄｉａｃ ｐｒｏｔｅｃｔｉｖｅ ｅｆｆｅｃｔ ｏｆ ｍｏｎｏｃｌｏｎａｌ ａｎｔｉｂｏｄｙ ｔｏ ＩＬ-' Ｃｈｉｎｅｓｅ Ｊｏｕｒｎａｌ ｏｆ Ｃａｒｄｉｏｌｏｇｙ Ｖｏｌ．２７， Ｎｏ．１, 1999, ｐ．２９-３２
JPN6012016812; ＯＨＴＳＵＫＡ，Ｔ． ｅｔ ａｌ．: 'Ｒｅｌａｔｉｏｎ ｏｆ ｃｉｒｃｕｌａｔｉｎｇ ｉｎｔｅｒｌｅｕｋｉｎ-６ ｔｏ ｌｅｆｔ ｖｅｎｔｒｉｃｕｌａｒ ｒｅｍｏｄｅｌｉｎｇ ｉｎ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｒｅｐｅｒｆｕｓｅｄ ａｎｔ' Ｃｌｉｎｉｃａｌ ｃａｒｄｉｏｌｏｇｙ Ｖｏｌ．２７， Ｎｏ．７, 2004, ｐ．４１７-４２０
JPN6012016814; ＰＵＨＡＫＫＡ，Ｍ． ｅｔ ａｌ．: 'Ｉｎｔｅｒｌｅｕｋｉｎ-６ ａｎｄ ｔｕｍｏｒ ｎｅｃｒｏｓｉｓ ｆａｃｔｏｒ ａｌｐｈａ ｉｎ ｒｅｌａｔｉｏｎ ｔｏ ｍｙｏｃａｒｄｉａｌ ｉｎｆａｒｃｔ ｓｉｚｅ ａｎｄ ｃｏｌｌａｇｅｎ ｆｏ' Ｊｏｕｒｎａｌ ｏｆ ｃａｒｄｉａｃ ｆａｉｌｕｒｅ Ｖｏｌ．９， Ｎｏ．４, 2003, ｐ．３２５-３３２
JPN6012016812; ＯＨＴＳＵＫＡ，Ｔ． ｅｔ ａｌ．: 'Ｒｅｌａｔｉｏｎ ｏｆ ｃｉｒｃｕｌａｔｉｎｇ ｉｎｔｅｒｌｅｕｋｉｎ-６ ｔｏ ｌｅｆｔ ｖｅｎｔｒｉｃｕｌａｒ ｒｅｍｏｄｅｌｉｎｇ ｉｎ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｒｅｐｅｒｆｕｓｅｄ ａｎｔ' Ｃｌｉｎｉｃａｌ ｃａｒｄｉｏｌｏｇｙ Ｖｏｌ．２７， Ｎｏ．７, 2004, ｐ．４１７-４２０
JPN6012016814; ＰＵＨＡＫＫＡ，Ｍ． ｅｔ ａｌ．: 'Ｉｎｔｅｒｌｅｕｋｉｎ-６ ａｎｄ ｔｕｍｏｒ ｎｅｃｒｏｓｉｓ ｆａｃｔｏｒ ａｌｐｈａ ｉｎ ｒｅｌａｔｉｏｎ ｔｏ ｍｙｏｃａｒｄｉａｌ ｉｎｆａｒｃｔ ｓｉｚｅ ａｎｄ ｃｏｌｌａｇｅｎ ｆｏ' Ｊｏｕｒｎａｌ ｏｆ ｃａｒｄｉａｃ ｆａｉｌｕｒｅ Ｖｏｌ．９， Ｎｏ．４, 2003, ｐ．３２５-３３２
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue