To provide a heat exchanger device capable of performing efficient heat exchange, compact and low in cost, and a heat exchange system.

The heat exchanger device comprises a heat exchanger 5 having first passages 2 through which a heat exchange medium 1 flows, and second passages 4 through which a cooling fluid 3 flows; and a mist generating means 6 having an injection nozzle 61 for spraying the cooling fluid 3, and a pressurizing supply means 62 for pressurizing and supplying the cooling fluid 3 to the injection nozzle 61, and generating a spray of cooling fluid 3 and supplying it into the second passages 4. A mist 3A is supplied into the heat exchanger 5, and the heat of vaporization of the mist efficiently takes away the heat of the heat exchange medium 1.