HEDGEHOG ANTAGONIST, METHOD AND USE RELATED THERETO

Title:

HEDGEHOG ANTAGONIST, METHOD AND USE RELATED THERETO

Document Type and Number:

Japanese Patent JP2009179630

Kind Code:

A

Abstract:

To inhibit angiogenesis and treat or prevent unwanted cell proliferation including tumors.

A composition and a method inhibit the hedgehog pathway with the use of an antagonist of the hedgehog pathway and, for example, the hedgehog antagonist is brought into contact with cells to overexpress a gli gene or is brought into contact with lung cells to stimulate surfactant production, and the hedgehog antagonist is selected from a small molecule of less than 2,000 daltons, a hedgehog antibody, a patched antibody, a smoothened antibody, a mutant hedgehog protein, an antisense nucleic acid, and a ribozyme.

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Inventors:

DUDEK HENRYK
PEPICELLI CARMEN
KARAVANOV IRINA

Application Number:

JP2009113082A

Publication Date:

August 13, 2009

Filing Date:

May 07, 2009

Export Citation:

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Assignee:

CURIS INC

International Classes:

A61K45/00; G01N33/50; A61K31/137; A61K31/138; A61K31/4025; A61K31/496; A61K31/517; A61K31/56; A61K31/58; A61K31/7088; A61K38/00; A61K39/395; A61K48/00; A61P1/00; A61P13/08; A61P13/10; A61P17/00; A61P35/00; A61P43/00; C07D239/91; C07D405/06; C07J69/00; C07J71/00; C07K16/18; C07K16/30; C12N15/09; C12Q1/68; G01N33/15; G01N33/574

Domestic Patent References:

JPH10215867A

1998-08-18

Foreign References:

WO1999052534A1	1999-10-21
WO2000015246A2	2000-03-23
WO2000041545A2	2000-07-20
WO2000025725A2	2000-05-11
WO1999052534A1	1999-10-21

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Attorney, Agent or Firm:

Axis International Patent Business Corporation

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