Title:
ヒト胚性幹細胞に由来する造血細胞
Document Type and Number:
Japanese Patent JP5364224
Kind Code:
B2
Abstract:
This invention provides a system for producing cells of the hematopoietic lineage from embryonic stem cells. Differentiation is conducted in the presence of hematogenic cytokines and other factors listed in the disclosure. The cell population that is obtained is remarkably enriched in CD45 +ve cells, a marker of early hematopoietic precursor with self-renewing capacity. Including a bone morphogenic protein during the differentiation process enhances the ability of the cell population to form secondary colonies. Because of the enormous replicative capacity of embryonic stem cells, this provides an important new commercial source of hematopoietic cells.
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Inventors:
Batia mickey
Madrenas Jokin
Felber Iris A.
Majmudar Anish Sen
Madrenas Jokin
Felber Iris A.
Majmudar Anish Sen
Application Number:
JP2003551273A
Publication Date:
December 11, 2013
Filing Date:
December 06, 2002
Export Citation:
Assignee:
GERON CORPORATION
International Classes:
C12N5/0735; C12N5/10; A61K35/28; A61K35/48; A61K35/545; A61K45/00; A61K48/00; A61P7/00; A61P29/00; A61P35/00; A61P35/02; A61P37/02; A61P43/00; C12N5/06; C12N5/078; A61K35/12
Other References:
Nature(1997)Vol.386,p.488-493
Molecular Medicine(2000)Vol.6,No.2,p.88-95
Blood(2001)Vol.98,No.2,p.335-342
Molecular Medicine(2000)Vol.6,No.2,p.88-95
Blood(2001)Vol.98,No.2,p.335-342
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi