HEMATOPOIETIC STEM CELL AND METHOD OF TREATMENT OF NEOVASCULAR EYEDISEASE THEREWITH

Japanese Patent JP2006166918

A

To provide cell populations capable of rescuing retinal blood vessels and neuronal networks in the eye.

Isolated, mammalian, adult bone marrow-derived, lineage negative hematopoietic stem cell populations (Lin-HSCs) contain endothelial progenitor cells (EPCs) capable of rescuing retinal blood vessels and neuronal networks in the eye. Preferably at least about 20% of the cells in the isolated Lin-HSCs express the cell surface antigen CD31. The isolated Lin-HSC populations develop anti-vascularization protein fragments of human tryptophanyl tRNA synthase and are useful for treatment of ocular vascular diseases. The Lin-HSCs are isolated by extracting bone marrow from an adult mammal, separating a plurality of monocytes, labeling the monocytes with biotin-conjugated lineage panel antibodies to lineage surface antigens, removing of monocytes that are positive for the lineage surface antigens from the plurality of monocytes, and recovering a Lin-HSC population containing EPCs.

FRIEDLANDER MARTIN
OTANI ATSUSHI
DA SILVA KAREN
HANEKAMP STACEY

JP2005373996A

June 29, 2006

December 27, 2005

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SCRIPPS RESEARCH INST

C12N5/078; C12N5/10; A61K35/28; A61K48/00; A61P7/02; A61P7/06; A61P9/10; A61P9/14; A61P25/00; A61P27/02; A61P27/12; A61P41/00; A61P43/00; C12N5/071; C12N5/074; C12N5/0789; C12N15/09; G01N33/48; G01N33/53; A61K35/12

JP2005538742A

2005-12-22

Yoshio Kawaguchi
Makoto Ono
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura

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