Title:
造血幹細胞及び該細胞による眼の血管新生性疾患の治療方法
Document Type and Number:
Japanese Patent JP4714682
Kind Code:
B2
Abstract:
Isolated, mammalian, adult bone marrow-derived, lineage negative hematopoietic stem cell populations (Lin - HSCs) containing endothelial progenitor cells (EPCs) have been transfected with therapeutically useful genes. The transfected isolated stem cell populations of the invention are useful for delivering genes to the eye for cell-based gene therapy. Methods of preparing transfected isolated stem cell populations of the invention, and methods of treating ocular diseases and injury are also described.
Inventors:
Friedlander, Martin
Atsushi Otani
Dasylva, Karen
Honeykamp, Stacey
Atsushi Otani
Dasylva, Karen
Honeykamp, Stacey
Application Number:
JP2006513372A
Publication Date:
June 29, 2011
Filing Date:
April 28, 2004
Export Citation:
Assignee:
The Scripts Research Institute
International Classes:
C12N5/078; C12N5/0789; A61K35/28; A61K48/00; A61P9/10; A61P27/02; A61P27/12; C12N5/071; C12N5/074; C12N5/10; C12N15/09; G01N33/48; G01N33/53; A61K35/12
Domestic Patent References:
| JP2005538742A |
Other References:
Blood(1997),Vol.90,No.12,p.5002-5012
Nat. Med.,2002年,Vol.8, No.9,1004-1010
Nat. Med.,2002年,Vol.8, No.9,1004-1010
Attorney, Agent or Firm:
Kawaguchi International Patent Office