Title:
Ｂ型肝炎抗ウイルス剤
Document Type and Number:
Japanese Patent JP7221277
Kind Code:
B2
Abstract:
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof:X-A-Y-L-R (I)which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
Inventors:
Chu, Yao-Ling
Khao, Hui
Gao, Sri
Kas, Jordan
Re, way
Pen, Xiaowen
Su, Byun - Cheol
Oru, Yat, Sun
Khao, Hui
Gao, Sri
Kas, Jordan
Re, way
Pen, Xiaowen
Su, Byun - Cheol
Oru, Yat, Sun
Application Number:
JP2020511772A
Publication Date:
February 13, 2023
Filing Date:
August 28, 2018
Export Citation:
Assignee:
Enanta Pharmaceuticals Incorporated
International Classes:
C07C317/44; A61K31/167; A61K31/336; A61K31/337; A61K31/341; A61K31/351; A61K31/357; A61K31/397; A61K31/40; A61K31/401; A61K31/4015; A61K31/415; A61K31/4164; A61K31/4192; A61K31/421; A61K31/425; A61K31/426; A61K31/439; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4427; A61K31/4439; A61K31/47; A61K31/513; A61K31/7028; A61K45/00; A61P31/20; C07C317/46; C07D205/04; C07D207/16; C07D207/26; C07D213/30; C07D213/61; C07D213/82; C07D215/14; C07D231/12; C07D233/54; C07D233/64; C07D239/26; C07D239/553; C07D249/04; C07D261/08; C07D263/20; C07D263/32; C07D263/34; C07D263/38; C07D263/56; C07D275/03; C07D277/24; C07D277/44; C07D303/34; C07D307/18; C07D307/22; C07D309/08; C07D317/32; C07D317/72; C07D401/04; C07D413/04; C07D451/04; C07D491/107; C07D493/04; C07H15/00
Domestic Patent References:
| JP6904970B2 | ||||
| JP2015506927A | ||||
| JP2016518437A | ||||
| JP2016509591A |
Foreign References:
| WO2016089990A1 | ||||
| WO2017136403A1 |
Other References:
BRADLEY D. ANDERSON,Part VII 製薬および製剤上の化学的問題,最新 創薬化学 下巻 THE PRACTICE OF MEDICINAL CHEMISTRY ,大塚 賢一郎 株式会社テクノミック,1998年,第347-365頁,第34章 塩形成による水溶性有機化合物の調製
Attorney, Agent or Firm:
Patent Attorney Corporation Asamura Patent Office
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